In 2024, we celebrate the 20th anniversary of the AANA Wellness Program, a milestone reflecting two decades of dedication to supporting CRNAs/nurse anesthesiologists and RRNAs through the challenges of substance use disorder and mental health. This journey includes pivotal moments like the creation of the AANA Helpline and the impact of COVID-19 on member wellness. Looking ahead, the AANA Wellness Program continues to innovate with new initiatives like the Wellness Ambassador Network, underscoring its commitment to holistic well-being and resilience in the anesthesia community.